Restoration of Neural System Functionality using Multi-Electrode Arrays and Electronic Neurons
The project aims to demonstrate through a pilot study the feasibility of the neuron-scale control of motor ganglia aimed to restore the functionality of damaged ganglia. This may pave the way toward a fundamentally new approach to neuro-functionality restoration intervention through electronic implants in the context of a range of diseases and disabling injuries (e.g. spinal cord damage).
We will use a prototype motor ganglion, the crab stomatogastric ganglion (STG), to demonstrate the proposed neuro-engineering technology. We will combine high speed optical recording of detailed neural activities, optogenetic temporary disabling of neurons, multi-electrode array (MEA) stimulation of neurons, and electronic implementation of computational model neurons to achieve our goal.